.Africa is the proposed Internet generic Top-Level Domain (gTLD) for the African and Pan African communities and users wherever they may reside. The .africa gTLD serves as a regional domain for individuals and entities based in and out of Africa.
The .Africa gTLD has not yet been delegated to any organization as registry operator. The .Africa application that was submitted by DotConnectAfrica Trust is now the subject of an unresolved disagreement with ICANN (DCA Trust vs ICANN) following an Independent Review Panel (IRP) Process that was invoked by DCA Trust under ICANN’s accountability mechanism in October 2013. The IRP was administrated by the International Center for Dispute Resolution (ICDR) of the American Arbitration Association (AAA) New York, US.
DCA Trust had passed all the new gTLD applicant evaluation criteria, but before the Initial Evaluation (IE) result was issued, a Governmental Advisory Committee GAC Objection Advice that had been issued in Beijing in April 2013 was later accepted by the ICANN Board in early June 2013 which caused the ICANN Board to instruct ICANN staff that DCA Trust’s .Africa new gTLD application will not be approved. This had caused the non-completion of the evaluation of DCA Trust’s application; which then led DCA Trust to challenge the ICANN Board decision through a series of accountability mechanism.
Africa is an epic poem in Latin hexameters by the 14th century Italian poet Petrarch (Francesco Petrarca). It tells the story of the Second Punic War, in which the Carthaginian general Hannibal invaded Italy, but Roman forces were eventually victorious after an invasion of north Africa led by Publius Cornelius Scipio Africanus, the epic poem's hero.
Africa and De viris illustribus were partially inspired by Petrarch's visit to Rome in 1337. According to Bergin and Wilson (p. ix). It seems very likely that the inspirational vision of the Eternal City must have been the immediate spur to the design of the Africa and probably De viris illustribus as well. After returning from his grand tour, the first sections of Africa were written in the valley of Vaucluse. Petrarch recalls
The fact that he abandoned it early on is not entirely correct since it was far along when he received two invitations (from Rome and from Paris) in September 1340 each asking him to accept the crown as poet laureate. A preliminary form of the poem was completed in time for the laurel coronation April 8, 1341 (Easter Sunday).
Africa is 2009 Perpetuum Jazzile album. By large most successful song from the album is a capella version of Toto's "Africa", the performance video of which has received more than 15 million YouTube views since its publishing in May 2009 until September 2013.
Rap may refer to:
Rap may refer to:
Rapper may refer to:
RAP may refer to:
Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular switches and are vital for effective signal transduction. There are two isoforms of the Rap1 protein, each encoded by a separate gene, RAP1A and RAP1B. Rap1 belongs to Ras-related protein family.
GTPases are inactive when in their GDP-bound form, and become active when they bind to GTP. GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs) regulate small GTPases, with GAPs promoting the GDP-bound (inactive) form, and GEFs promoting the GTP-bound (active) form. When bound to GTP, small GTPases regulate myriad cellular processes. These proteins are divided into families depending on their protein structure, and the most well studied is the Ras superfamily, of which Rap1 is a member. Whereas Ras is known for its role in cell proliferation and survival, Rap1 is predominantly involved in cell adhesion and cell junction formation. Ras and Rap are regulated by different sets of guanine nucleotide exchange factors and GTPase-activating proteins, thus providing one level of specificity.
RAP6 is the abbreviation for Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. RAP6 was discovered by Alejandro Barbieri and his group of researchers (Christine Hunker, Adriana Galvis, Ivan Kruk, Hugo Giambini, Lina Torres and Maria Luisa Veisaga) working at Florida International University.
This novel human protein has been reported to be involved in membrane trafficking. It has been shown that RAP6 has a guanine nucleotide exchange factor (GEF) activity specific to Rab5 and a GTPase activating protein (GAP) activity specific to RAS.
The original GeneBank Identifications (GIs) have been published in the NCBI Nucleotide databases with GIs 77176718 and 77176720. Since then, many names have been coined to the validated protein such as RabGEF1, GeneID: 27342. RAP6 belongs to the family of the GAPVD1, GeneID: 26130